OvCaRe Publications

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1. Carey, M.S., Agarwal, R., Gilks, B., Swenerton, K., Kalloger, S., Santos, J., Ju, Z., Lu, Y., Zhang, F., Coombes, K.R., Miller, D., Huntsman, D., Mills, G.B. and Hennessy, B.T. (2010) Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy Clin Cancer Res, 16: p. 2852-60. [PMID: 20460476]

2. Chen, J., An, B.S., So, W.K., Cheng, L., Hammond, G.L. and Leung, P.C. (2010) Gonadotropin-releasing hormone-I-mediated activation of progesterone receptor contributes to gonadotropin alpha-subunit expression in mouse gonadotrophs Endocrinology, 151: p. 1204-11. [PMID: 20051488]

3. Cheung, L.W., Leung, P.C. and Wong, A.S. (2010) Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer Oncogene, 29: p. 2427-40. [PMID: 20118984]

4. Clarke, B.A. and Gilks, C.B. (2010) Endometrial carcinoma: controversies in histopathological assessment of grade and tumour cell type J Clin Pathol, 63: p. 410-5. [PMID: 20418232]

5. Guo, J., Schally, A.V., Zarandi, M., Varga, J. and Leung, P.C. (2010) Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway Reprod Biol Endocrinol, 8: p. 54. [PMID: 20509930]

6. Kim, K.Y., Kim, S.U., Leung, P.C., Jeung, E.B. and Choi, K.C. (2010) Influence of the prodrugs 5-fluorocytosine and CPT-11 on ovarian cancer cells using genetically engineered stem cells: tumor-tropic potential and inhibition of ovarian cancer cell growth Cancer Sci. [PMID: 20132217]

7. Kobel, M., Kalloger, S.E., Baker, P.M., Ewanowich, C.A., Arseneau, J., Zherebitskiy, V., Abdulkarim, S., Leung, S., Duggan, M.A., Fontaine, D., Parker, R., Huntsman, D.G. and Gilks, C.B. (2010) Diagnosis of Ovarian Carcinoma Cell Type is Highly Reproducible: A Transcanadian Study Am J Surg Pathol. [PMID: 20505499]

8. Kobel, M., Kalloger, S.E., Huntsman, D.G., Santos, J.L., Swenerton, K.D., Seidman, J.D. and Gilks, C.B. (2010) Differences in tumor type in low-stage versus high-stage ovarian carcinomas Int J Gynecol Pathol, 29: p. 203-11. [PMID: 20407318]

9. Lau, M.T., Wong, A.S. and Leung, P.C. (2010) Gonadotropins Induce Tumor Cell Migration and Invasion by Increasing Cyclooxygenases Expression and Prostaglandin E2 Production in Human Ovarian Cancer Cells Endocrinology. [PMID: 20392831]

10. Wang, T.T., Wu, Y.T., Dong, M.Y., Sheng, J.Z., Leung, P.C. and Huang, H.F. (2010) G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve Fertil Steril. [PMID: 20451184]

11. Webb, J.R., Wick, D.A., Nielsen, J.S., Tran, E., Milne, K., McMurtrie, E. and Nelson, B.H. (2010) Profound elevation of CD8(+) T cells expressing the intraepithelial lymphocyte marker CD103 (alpha(E)/beta(7) Integrin) in high-grade serous ovarian cancer Gynecol Oncol. [PMID: 20541243]

12. Zhang, Y., Huang, Q., Cheng, J.C., Nishi, Y., Yanase, T., Huang, H.F. and Leung, P.C. (2010) Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells Reprod Biol Endocrinol, 8: p. 61. [PMID: 20540809]

13. Gainford, M.C., Tinker, A., Carter, J., Petru, E., Nicklin, J., Quinn, M., Hammond, I., Elit, L., Lenhard, M. and Friedlander, M. (2010). Malignant transformation within ovarian dermoid cysts: an audit of treatment received and patient outcomes. an australia new zealand gynaecological oncology group (ANZGOG) and gynaecologic cancer intergroup (GCIG) study Int J Gynecol Cancer, 20: p. 75-81. [PMID: 20130506]

14. Gilks, C.B. (2010). Molecular abnormalities in ovarian cancer subtypes other than high-grade serous carcinoma J Oncol, 2010: p. 740968. [PMID: 20069115]

15. Goya, R., Sun, M.G., Morin, R.D., Leung, G., Ha, G., Wiegand, K.C., Senz, J., Crisan, A., Marra, M.A., Hirst, M., Huntsman, D., Murphy, K.P., Aparicio, S. and Shah, S.P. (2010). SNVMix: predicting single nucleotide variants from next-generation sequencing of tumors Bioinformatics, 26: p. 730-6. [PMID: 20130035]

16. Kobel, M., Kalloger, S.E., Santos, J.L., Huntsman, D.G., Gilks, C.B. and Swenerton, K.D. (2010). Tumor type and substage predict survival in stage I and II ovarian carcinoma: insights and implications Gynecol Oncol, 116: p. 50-6. [PMID: 19822358]

17. Mackay, H.J., Tinker, A., Winquist, E., Thomas, G., Swenerton, K., Oza, A., Sederias, J., Ivy, P. and Eisenhauer, E.A. (2010). A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184 Gynecol Oncol, 116: p. 163-7. [PMID: 19740535]

18. Madore, J., Ren, F., Filali-Mouhim, A., Sanchez, L., Kobel, M., Tonin, P.N., Huntsman, D., Provencher, D.M. and Mes-Masson, A.M. (2010). Characterization of the molecular differences between ovarian endometrioid carcinoma and ovarian serous carcinoma J Pathol, 220: p. 392-400. [PMID: 19967725]

19. Maines-Bandiera, S., Woo, M.M., Borugian, M., Molday, L.L., Hii, T., Gilks, B., Leung, P.C., Molday, R.S. and Auersperg, N. (2010). Oviductal glycoprotein (OVGP1, MUC9): a differentiation-based mucin present in serum of women with ovarian cancer Int J Gynecol Cancer, 20: p. 16-22. [PMID: 20130498]

20. Tabrizi, A.D., Kalloger, S.E., Kobel, M., Cipollone, J., Roskelley, C.D., Mehl, E. and Gilks, C.B. (2010). Primary ovarian mucinous carcinoma of intestinal type: significance of pattern of invasion and immunohistochemical expression profile in a series of 31 cases Int J Gynecol Pathol, 29: p. 99-107. [PMID: 20173494]

21. Zheng, J., Mercado-Uribe, I., Rosen, D.G., Chang, B., Liu, P., Yang, G., Malpica, A., Noara, H., Auersperg, N., Mills, G.B., Bast, R.C. and Liu, J. (2010). Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment Cell Cycle, 9: p. 140-6. [PMID: 20016289]

22. An, B.S., Poon, S.L., So, W.K., Hammond, G.L. and Leung, P.C. (2009). Rapid effect of GNRH1 on follicle-stimulating hormone beta gene expression in LbetaT2 mouse pituitary cells requires the progesterone receptor Biol Reprod, 81: p. 243-9. [PMID: 19357364]

23. Chen, J., An, B.S., Cheng, L., Hammond, G.L. and Leung, P.C. (2009). Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs Endocrinology, 150: p. 4583-93. [PMID: 19574399]

24. Choi, J.H., Chen, C.L., Poon, S.L., Wang, H.S. and Leung, P.C. (2009). Gonadotropin-stimulated epidermal growth factor receptor expression in human ovarian surface epithelial cells: involvement of cyclic AMP-dependent exchange protein activated by cAMP pathway Endocr Relat Cancer, 16: p. 179-88. [PMID: 19022848]

25. Clarke, B., Tinker, A.V., Lee, C.H., Subramanian, S., van de Rijn, M., Turbin, D., Kalloger, S., Han, G., Ceballos, K., Cadungog, M.G., Huntsman, D.G., Coukos, G. and Gilks, C.B. (2009). Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss Mod Pathol, 22: p. 393-402. [PMID: 19060844]

26. Espinosa, I., Beck, A.H., Lee, C.H., Zhu, S., Montgomery, K.D., Marinelli, R.J., Ganjoo, K.N., Nielsen, T.O., Gilks, C.B., West, R.B. and van de Rijn, M. (2009). Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma Am J Pathol, 174: p. 2347-56. [PMID: 19443701]

27. Etemadmoghadam, D., deFazio, A., Beroukhim, R., Mermel, C., George, J., Getz, G., Tothill, R., Okamoto, A., Raeder, M.B., Harnett, P., Lade, S., Akslen, L.A., Tinker, A.V., Locandro, B., Alsop, K., Chiew, Y.E., Traficante, N., Fereday, S., Johnson, D., Fox, S., Sellers, W., Urashima, M., Salvesen, H.B., Meyerson, M. and Bowtell, D. (2009). Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas Clin Cancer Res, 15: p. 1417-27. [PMID: 19193619]

28. Gilks, C.B. and Prat, J. (2009). Ovarian carcinoma pathology and genetics: recent advances Hum Pathol, 40: p. 1213-23. [PMID: 19552940]

29. Huang, Q., Cheung, A.P., Zhang, Y., Huang, H.F., Auersperg, N. and Leung, P.C. (2009). Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation Am J Physiol Endocrinol Metab, 296: p. E1344-53. [PMID: 19366876]

30. Klausen, C., Leung, P.C. and Auersperg, N. (2009). Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin Mol Cancer Res, 7: p. 1425-37. [PMID: 19723874]

31. Kobel, M., Gilks, C.B. and Huntsman, D.G. (2009). Adult-type granulosa cell tumors and FOXL2 mutation Cancer Res, 69: p. 9160-2. [PMID: 19996294]

32. Kobel, M., Gilks, C.B. and Huntsman, D.G. (2009). Dicer and Drosha in ovarian cancer N Engl J Med, 360: p. 1150-1; author reply 1151. [PMID: 19279349]

33. Kobel, M., Kalloger, S.E., Carrick, J., Huntsman, D., Asad, H., Oliva, E., Ewanowich, C.A., Soslow, R.A. and Gilks, C.B. (2009). A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary Am J Surg Pathol, 33: p. 14-21. [PMID: 18830127]

34. Kobel, M., Xu, H., Bourne, P.A., Spaulding, B.O., Shih Ie, M., Mao, T.L., Soslow, R.A., Ewanowich, C.A., Kalloger, S.E., Mehl, E., Lee, C.H., Huntsman, D. and Gilks, C.B. (2009). IGF2BP3 (IMP3) expression is a marker of unfavorable prognosis in ovarian carcinoma of clear cell subtype Mod Pathol, 22: p. 469-75. [PMID: 19136932]

35. Lee, C.H., Subramanian, S., Beck, A.H., Espinosa, I., Senz, J., Zhu, S.X., Huntsman, D., van de Rijn, M. and Gilks, C.B. (2009). MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary PLoS ONE, 4: p. e7314. [PMID: 19798417]

36. Lin, Q., Poon, S.L., Chen, J., Cheng, L., HoYuen, B. and Leung, P.C. (2009). Leptin interferes with 3',5'-cyclic adenosine monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cells Reprod Biol Endocrinol, 7: p. 115. [PMID: 19849856]

37. Liu, J., Maccalman, C.D., Wang, Y.L. and Leung, P.C. (2009). Promotion of human trophoblasts invasion by gonadotropin-releasing hormone (GnRH) I and GnRH II via distinct signaling pathways Mol Endocrinol, 23: p. 1014-21. [PMID: 19372239]

38. Liu, P., Khurana, A., Rattan, R., He, X., Kalloger, S., Dowdy, S., Gilks, B. and Shridhar, V. (2009). Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancer Cancer Res, 69: p. 4843-50. [PMID: 19487294]

39. McAlpine, J.N., Wiegand, K.C., Vang, R., Ronnett, B.M., Adamiak, A., Kobel, M., Kalloger, S.E., Swenerton, K.D., Huntsman, D.G., Gilks, C.B. and Miller, D.M. (2009). HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy BMC Cancer, 9: p. 433. [PMID: 20003286]

40. Milne, K., Kobel, M., Kalloger, S.E., Barnes, R.O., Gao, D., Gilks, C.B., Watson, P.H. and Nelson, B.H. (2009). Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors PLoS ONE, 4: p. e6412. [PMID: 19641607]

41. Nelson, B.H. (2009). IDO and outcomes in ovarian cancer Gynecol Oncol, 115: p. 179-80. [PMID: 19822256]

42. Ota, T., Klausen, C., Salamanca, M.C., Woo, H.L., Leung, P.C. and Auersperg, N. (2009). Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells Differentiation, 77: p. 162-71. [PMID: 19281776]

43. Park, D.W., Choi, K.C., MacCalman, C.D. and Leung, P.C. (2009). Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase Reprod Biol Endocrinol, 7: p. 81. [PMID: 19656390]

44. Park, S.H., Kim, K.Y., An, B.S., Choi, J.H., Jeung, E.B., Leung, P.C. and Choi, K.C. (2009). Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38 J Reprod Dev, 55: p. 23-9. [PMID: 18854640]

45. Poon, S.L., Hammond, G.T. and Leung, P.C. (2009). Epidermal growth factor-induced GnRH-II synthesis contributes to ovarian cancer cell invasion Mol Endocrinol, 23: p. 1646-56. [PMID: 19608641]

46. Salvador, S., Gilks, B., Kobel, M., Huntsman, D., Rosen, B. and Miller, D. (2009). The fallopian tube: primary site of most pelvic high-grade serous carcinomas Int J Gynecol Cancer, 19: p. 58-64. [PMID: 19258943]

47. Schrader, K.A., Gorbatcheva, B., Senz, J., Heravi-Moussavi, A., Melnyk, N., Salamanca, C., Maines-Bandiera, S., Cooke, S.L., Leung, P., Brenton, J.D., Gilks, C.B., Monahan, J. and Huntsman, D.G. (2009). The specificity of the FOXL2 c.402C>G Somatic mutation: a survey of solid tumors PLoS ONE, 4: p. e7988. [PMID: 19956657]

48. Shah, S.P., Kobel, M., Senz, J., Morin, R.D., Clarke, B.A., Wiegand, K.C., Leung, G., Zayed, A., Mehl, E., Kalloger, S.E., Sun, M., Giuliany, R., Yorida, E., Jones, S., Varhol, R., Swenerton, K.D., Miller, D., Clement, P.B., Crane, C., Madore, J., Provencher, D., Leung, P., Defazio, A., Khattra, J., Turashvili, G., Zhao, Y., Zeng, T., Glover, J.N., Vanderhyden, B., Zhao, C., Parkinson, C.A., Jimenez-Linan, M., Bowtell, D.D., Mes-Masson, A.M., Brenton, J.D., Aparicio, S.A., Boyd, N., Hirst, M., Gilks, C.B., Marra, M. and Huntsman, D.G. (2009). Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary N Engl J Med, epub ahead of print. [PMID: 19516027]

49. Shi, F.T., Cheung, A.P., Huang, H.F. and Leung, P.C. (2009). Effects of endogenous growth differentiation factor 9 on activin A-induced inhibin B production in human granulosa-lutein cells J Clin Endocrinol Metab, 94: p. 5108-16. [PMID: 19846738]

50. Shi, F.T., Cheung, A.P. and Leung, P.C. (2009). Growth differentiation factor 9 enhances activin a-induced inhibin B production in human granulosa cells Endocrinology, 150: p. 3540-6. [PMID: 19423755]

51. Tang, L., Zhang, Y., Pan, H., Luo, Q., Zhu, X.M., Dong, M.Y., Leung, P.C., Sheng, J.Z. and Huang, H.F. (2009). Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell Reprod Biol Endocrinol, 7: p. 144. [PMID: 19968870]

52. Wu, H.M., Cheng, J.C., Wang, H.S., Huang, H.Y., MacCalman, C.D. and Leung, P.C. (2009). Gonadotropin-releasing hormone type II induces apoptosis of human endometrial cancer cells by activating GADD45alpha Cancer Res, 69: p. 4202-8. [PMID: 19366794]

53. Wu, H.M., Wang, H.S., Huang, H.Y., Soong, Y.K., MacCalman, C.D. and Leung, P.C. (2009). GnRH signaling in intrauterine tissues Reproduction, 137: p. 769-77. [PMID: 19208750]

54. Anglesio, M.S., Arnold, J.M., George, J., Tinker, A.V., Tothill, R., Waddell, N., Simms, L., Locandro, B., Fereday, S., Traficante, N., Russell, P., Sharma, R., Birrer, M.J., deFazio, A., Chenevix-Trench, G. and Bowtell, D.D. (2008). Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors Mol Cancer Res, 6: p. 1678-90. [PMID: 19010816]

55. Astanehe, A., Arenillas, D., Wasserman, W.W., Leung, P.C., Dunn, S.E., Davies, B.R., Mills, G.B. and Auersperg, N. (2008). Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer J Cell Sci, 121: p. 664-74. [PMID: 18270270]

56. Auersperg, N., Woo, M.M. and Gilks, C.B. (2008). The origin of ovarian carcinomas: a developmental view Gynecol Oncol, 110: p. 452-4. [PMID: 18603285]

57. Brown, L.A., Kalloger, S.E., Miller, M.A., Shih Ie, M., McKinney, S.E., Santos, J.L., Swenerton, K., Spellman, P.T., Gray, J., Gilks, C.B. and Huntsman, D.G. (2008). Amplification of 11q13 in ovarian carcinoma Genes Chromosomes Cancer, 47: p. 481-9. [PMID: 18314909]

58. Dimple, C., Nair, S.S., Rajhans, R., Pitcheswara, P.R., Liu, J., Balasenthil, S., Le, X.F., Burow, M.E., Auersperg, N., Tekmal, R.R., Broaddus, R.R. and Vadlamudi, R.K. (2008). Role of PELP1/MNAR signaling in ovarian tumorigenesis Cancer Res, 68: p. 4902-9. [PMID: 18559538]

59. Gilks, C.B., Ionescu, D.N., Kalloger, S.E., Kobel, M., Irving, J., Clarke, B., Santos, J., Le, N., Moravan, V. and Swenerton, K. (2008). Tumor cell type can be reproducibly diagnosed and is of independent prognostic significance in patients with maximally debulked ovarian carcinoma Hum Pathol, 39: p. 1239-51. [PMID: 18602670]

60. Han, G., Gilks, C.B., Leung, S., Ewanowich, C.A., Irving, J.A., Longacre, T.A. and Soslow, R.A. (2008). Mixed ovarian epithelial carcinomas with clear cell and serous components are variants of high-grade serous carcinoma: an interobserver correlative and immunohistochemical study of 32 cases Am J Surg Pathol, 32: p. 955-64. [PMID: 18460981]

61. Hennessy, B.T., Murph, M., Nanjundan, M., Carey, M., Auersperg, N., Almeida, J., Coombes, K.R., Liu, J., Lu, Y., Gray, J.W. and Mills, G.B. (2008). Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead Adv Exp Med Biol, 617: p. 23-40. [PMID: 18497028]

62. Hong, I.S., Cheung, A.P. and Leung, P.C. (2008). Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells J Clin Endocrinol Metab, 93: p. 3179-85. [PMID: 18477660]

63. Hoskins, P.J., Le, N., Ellard, S., Lee, U., Martin, L.A., Swenerton, K.D. and Tinker, A.V. (2008). Carboplatin plus paclitaxel for advanced or recurrent uterine malignant mixed mullerian tumors. The British Columbia Cancer Agency experience Gynecol Oncol, 108: p. 58-62. [PMID: 17935761]

64. Kobel, M., Huntsman, D. and Gilks, C.B. (2008). Critical molecular abnormalities in high-grade serous carcinoma of the ovary Expert Rev Mol Med, 10: p. e22. [PMID: 18671886]

65. Kobel, M., Kalloger, S.E., Boyd, N., McKinney, S., Mehl, E., Palmer, C., Leung, S., Bowen, N.J., Ionescu, D.N., Rajput, A., Prentice, L.M., Miller, D., Santos, J., Swenerton, K., Gilks, C.B. and Huntsman, D. (2008). Ovarian carcinoma subtypes are different diseases: implications for biomarker studies PLoS Med, 5: p. e232. [PMID: 19053170]

66. McIntosh, M. anderson, G., Drescher, C., Hanash, S., Urban, N., Brown, P., Gambhir, S.S., Coukos, G., Laird, P.W., Nelson, B. and Palmer, C. (2008). Ovarian cancer early detection claims are biased Clin Cancer Res, 14: p. 7574; author reply 7577-9. [PMID: 18948385]

67. Milne, K., Barnes, R.O., Girardin, A., Mawer, M.A., Nesslinger, N.J., Ng, A., Nielsen, J.S., Sahota, R., Tran, E., Webb, J.R., Wong, M.Q., Wick, D.A., Wray, A., McMurtrie, E., Kobel, M., Kalloger, S.E., Gilks, C.B., Watson, P.H. and Nelson, B.H. (2008). Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer PLoS ONE, 3: p. e3409. [PMID: 18923710]

68. Natesampillai, S., Kerkvliet, J., Leung, P.C. and Veldhuis, J.D. (2008). Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells Am J Physiol Endocrinol Metab, 294: p. E385-91. [PMID: 18056793]

69. Nelson, B.H. (2008). The impact of T-cell immunity on ovarian cancer outcomes Immunol Rev, 222: p. 101-16. [PMID: 18363996]

70. Ota, T., Asahina, H., Park, S.H., Huang, Q., Minegishi, T., Auersperg, N. and Leung, P.C. (2008). HOX cofactors expression and regulation in the human ovary Reprod Biol Endocrinol, 6: p. 49. [PMID: 18973687]

71. Palmer, C., Duan, X., Hawley, S., Scholler, N., Thorpe, J.D., Sahota, R.A., Wong, M.Q., Wray, A., Bergan, L.A., Drescher, C.W., McIntosh, M.W., Brown, P.O., Nelson, B.H. and Urban, N. (2008). Systematic evaluation of candidate blood markers for detecting ovarian cancer PLoS ONE, 3: p. e2633. [PMID: 18612378]

72. Pinke, D.E., Kalloger, S.E., Francetic, T., Huntsman, D.G. and Lee, J.M. (2008). The prognostic significance of elongation factor eEF1A2 in ovarian cancer Gynecol Oncol, 108: p. 561-8. [PMID: 18164751]

73. Press, J.Z., De Luca, A., Boyd, N., Young, S., Troussard, A., Ridge, Y., Kaurah, P., Kalloger, S.E., Blood, K.A., Smith, M., Spellman, P.T., Wang, Y., Miller, D.M., Horsman, D., Faham, M., Gilks, C.B., Gray, J. and Huntsman, D.G. (2008). Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities BMC Cancer, 8: p. 17. [PMID: 18208621]

74. Press, J.Z., Kenyon, J.A., Xue, H., Miller, M.A., De Luca, A., Miller, D.M., Huntsman, D.G., Gilks, C.B., McAlpine, J.N. and Wang, Y.Z. (2008). Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy Gynecol Oncol, 110: p. 256-64. [PMID: 18547621]

75. Ronnett, B.M., Yemelyanova, A.V., Vang, R., Gilks, C.B., Miller, D., Gravitt, P.E. and Kurman, R.J. (2008). Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms Am J Surg Pathol, 32: p. 1835-53. [PMID: 18813124]

76. Salvador, S., Rempel, A., Soslow, R.A., Gilks, B., Huntsman, D. and Miller, D. (2008). Chromosomal instability in fallopian tube precursor lesions of serous carcinoma and frequent monoclonality of synchronous ovarian and fallopian tube mucosal serous carcinoma Gynecol Oncol, 110: p. 408-17. [PMID: 18597838]

77. Singh, R., Graves, M.L., Roskelley, C.D., Giritharan, G. and Rajamahendran, R. (2008). Gonadotropin releasing hormone receptor gene and protein expression and immunohistochemical localization in bovine uterus and oviducts Domest Anim Endocrinol, 34: p. 319-26. [PMID: 18035513]

78. Sun, Y., Wong, N., Guan, Y., Salamanca, C.M., Cheng, J.C., Lee, J.M., Gray, J.W. and Auersperg, N. (2008). The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas Int J Cancer, 123: p. 1761-9. [PMID: 18661515]

79. Tothill, R.W., Tinker, A.V., George, J., Brown, R., Fox, S.B., Lade, S., Johnson, D.S., Trivett, M.K., Etemadmoghadam, D., Locandro, B., Traficante, N., Fereday, S., Hung, J.A., Chiew, Y.E., Haviv, I., Gertig, D., DeFazio, A. and Bowtell, D.D. (2008). Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome Clin Cancer Res, 14: p. 5198-208. [PMID: 18698038]

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81. Woo, M.M., Salamanca, C.M., Miller, M., Symowicz, J., Leung, P.C., Oliveira, C., Ehlen, T.G., Gilks, C.B., Huntsman, D. and Auersperg, N. (2008). Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas Int J Gynecol Cancer, 18: p. 1234-47. [PMID: 18217967]

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83. Wu, C., Cipollone, J., Maines-Bandiera, S., Tan, C., Karsan, A., Auersperg, N. and Roskelley, C.D. (2008). The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression Differentiation, 76: p. 193-205. [PMID: 17608733]

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86. Guan, Y., Kuo, W.L., Stilwell, J.L., Takano, H., Lapuk, A.V., Fridlyand, J., Mao, J.H., Yu, M., Miller, M.A., Santos, J.L., Kalloger, S.E., Carlson, J.W., Ginzinger, D.G., Celniker, S.E., Mills, G.B., Huntsman, D.G. and Gray, J.W. (2007). Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer Clin Cancer Res, 13: p. 5745-55. [PMID: 17908964]

87. He, X., Pool, M., Darcy, K.M., Lim, S.B., Auersperg, N., Coon, J.S. and Beck, W.T. (2007). Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro Oncogene, 26: p. 4961-8. [PMID: 17310993]

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91. Prentice, L.M., Klausen, C., Kalloger, S., Kobel, M., McKinney, S., Santos, J.L., Kenney, C., Mehl, E., Gilks, C.B., Leung, P., Swenerton, K., Huntsman, D.G. and Aparicio, S.A. (2007). Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma BMC Med, 5: p. 33. [PMID: 18005407]

92. Schumacher, J.J., Dings, R.P., Cosin, J., Subramanian, I.V., Auersperg, N. and Ramakrishnan, S. (2007). Modulation of angiogenic phenotype alters tumorigenicity in rat ovarian epithelial cells Cancer Res, 67: p. 3683-90. [PMID: 17440080]

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98. Brewer, M., Kirkpatrick, N.D., Wharton, J.T., Wang, J., Hatch, K., Auersperg, N., Utzinger, U., Gershenson, D., Bast, R. and Zou, C. (2006). 4-HPR modulates gene expression in ovarian cells Int J Cancer, 119: p. 1005-13. [PMID: 16570282]

99. Brown, L.A., Irving, J., Parker, R., Kim, H., Press, J.Z., Longacre, T.A., Chia, S., Magliocco, A., Makretsov, N., Gilks, B., Pollack, J. and Huntsman, D. (2006). Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas Gynecol Oncol, 100: p. 264-70. [PMID: 16236351]

100. Cheung, L.W., Au, S.C., Cheung, A.N., Ngan, H.Y., Tombran-Tink, J., Auersperg, N. and Wong, A.S. (2006). Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells Endocrinology, 147: p. 4179-91. [PMID: 16777976]

101. Choi, J.H., Choi, K.C., Auersperg, N. and Leung, P.C. (2006). Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid by gonadotropins in human immortalized ovarian surface epithelium and ovarian cancer cells Endocr Relat Cancer, 13: p. 641-51. [PMID: 16728589]

102. Choi, J.H., Choi, K.C., Auersperg, N. and Leung, P.C. (2006). Gonadotropins activate proteolysis and increase invasion through protein kinase A and phosphatidylinositol 3-kinase pathways in human epithelial ovarian cancer cells Cancer Res, 66: p. 3912-20. [PMID: 16585220]

103. Choi, J.H., Gilks, C.B., Auersperg, N. and Leung, P.C. (2006). Immunolocalization of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and type I GnRH receptor during follicular development in the human ovary J Clin Endocrinol Metab, 91: p. 4562-70. [PMID: 16954155]

104. de Lemos, M.L., Hamata, L., Conklin, J. and Swenerton, K. (2006). Potential underdosing of carboplatin in gynecological malignancies Gynecol Oncol, 102: p. 599. [PMID: 16815537]

105. de Lemos, M.L., Hsieh, T., Hamata, L., Levin, A., Swenerton, K., Djurdjev, O., Vu, T., Hu, F., Conklin, J. and Malfair Taylor, S.C. (2006). Evaluation of predictive formulae for glomerular filtration rate for carboplatin dosing in gynecological malignancies Gynecol Oncol, 103: p. 1063-9. [PMID: 16875719]

106. Erkanli, A., Taylor, D.D., Dean, D., Eksir, F., Egger, D., Geyer, J., Nelson, B.H., Stone, B., Fritsche, H.A. and Roden, R.B. (2006). Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection Cancer Res, 66: p. 1792-8. [PMID: 16452240]

107. Kim, K.Y., Choi, K.C., Auersperg, N. and Leung, P.C. (2006). Mechanism of gonadotropin-releasing hormone (GnRH)-I and -II-induced cell growth inhibition in ovarian cancer cells: role of the GnRH-I receptor and protein kinase C pathway Endocr Relat Cancer, 13: p. 211-20. [PMID: 16601289]

108. Mao, T.L., Hsu, C.Y., Yen, M.J., Gilks, B., Sheu, J.J., Gabrielson, E., Vang, R., Cope, L., Kurman, R.J., Wang, T.L. and Shih Ie, M. (2006). Expression of Rsf-1, a chromatin-remodeling gene, in ovarian and breast carcinoma Hum Pathol, 37: p. 1169-75. [PMID: 16938522]

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110. Plante, M., Lau, S., Brydon, L., Swenerton, K., LeBlanc, R. and Roy, M. (2006). Neoadjuvant chemotherapy followed by vaginal radical trachelectomy in bulky stage IB1 cervical cancer: case report Gynecol Oncol, 101: p. 367-70. [PMID: 16542714]

111. Xu, G., Zhou, H., Wang, Q., Auersperg, N. and Peng, C. (2006). Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines Mol Cancer Res, 4: p. 235-46. [PMID: 16603637]

112. Auersperg, N. (2005). Re: "Cultures of ovarian surface epithelium from women with and without a hereditary predisposition to develop female adnexal carcinoma" Gynecol Oncol, 97: p. 302-4; author reply 304-5. [PMID: 15790484]

113. Brewer, M., Wharton, J.T., Wang, J., McWatters, A., Auersperg, N., Gershenson, D., Bast, R. and Zou, C. (2005). In vitro model of normal, immortalized ovarian surface epithelial and ovarian cancer cells for chemoprevention of ovarian cancer Gynecol Oncol, 98: p. 182-92. [PMID: 15907982]

114. Choi, J.H., Choi, K.C., Auersperg, N. and Leung, P.C. (2005). Gonadotropins upregulate the epidermal growth factor receptor through activation of mitogen-activated protein kinases and phosphatidyl-inositol-3-kinase in human ovarian surface epithelial cells Endocr Relat Cancer, 12: p. 407-21. [PMID: 15947112]

115. Dark, G.G., Calvert, A.H., Grimshaw, R., Poole, C., Swenerton, K., Kaye, S., Coleman, R., Jayson, G., Le, T., Ellard, S., Trudeau, M., Vasey, P., Hamilton, M., Cameron, T., Barrett, E., Walsh, W., McIntosh, L. and Eisenhauer, E.A. (2005). Randomized trial of two intravenous schedules of the topoisomerase I inhibitor liposomal lurtotecan in women with relapsed epithelial ovarian cancer: a trial of the national cancer institute of Canada clinical trials group J Clin Oncol, 23: p. 1859-66. [PMID: 15699482]

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121. Kim, K.Y., Choi, K.C., Park, S.H., Auersperg, N. and Leung, P.C. (2005). Extracellular signal-regulated protein kinase, but not c-Jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation J Clin Endocrinol Metab, 90: p. 1670-7. [PMID: 15598681]

122. Le, L.H., Swenerton, K.D., Elit, L., Provencher, D.M., Stuart, G.C., Le, T., Lee, U., Rodgers, A., Pond, G.R., Hu, H. and Oza, A.M. (2005). Phase II multicenter open-label study of carboplatin and pegylated liposomal doxorubicin in uterine and cervical malignancies Int J Gynecol Cancer, 15: p. 799-806. [PMID: 16174227]

123. Lee, C.H., Huntsman, D.G., Cheang, M.C., Parker, R.L., Brown, L., Hoskins, P., Miller, D. and Gilks, C.B. (2005). Assessment of Her-1, Her-2, And Her-3 expression and Her-2 amplification in advanced stage ovarian carcinoma Int J Gynecol Pathol, 24: p. 147-52. [PMID: 15782071]

124. Lee, C.H., Xue, H., Sutcliffe, M., Gout, P.W., Huntsman, D.G., Miller, D.M., Gilks, C.B. and Wang, Y.Z. (2005). Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models Gynecol Oncol, 96: p. 48-55. [PMID: 15589579]

125. Ludwick, C., Gilks, C.B., Miller, D., Yaziji, H. and Clement, P.B. (2005). Aggressive behavior of stage I ovarian mucinous tumors lacking extensive infiltrative invasion: a report of four cases and review of the literature Int J Gynecol Pathol, 24: p. 205-17. [PMID: 15968194]

126. Pon, Y.L., Auersperg, N. and Wong, A.S. (2005). Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase A pathway J Biol Chem, 280: p. 15438-48. [PMID: 15701645]

127. Smith-Beckerman, D.M., Fung, K.W., Williams, K.E., Auersperg, N., Godwin, A.K. and Burlingame, A.L. (2005). Proteome changes in ovarian epithelial cells derived from women with BRCA1 mutations and family histories of cancer Mol Cell Proteomics, 4: p. 156-68. [PMID: 15591324]

128. Symowicz, J., Adley, B.P., Woo, M.M., Auersperg, N., Hudson, L.G. and Stack, M.S. (2005). Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells Cancer Res, 65: p. 2234-42. [PMID: 15781636]

129. Tai, C.J., Chang, S.J., Chien, L.Y., Leung, P.C. and Tzeng, C.R. (2005). Adenosine triphosphate induces activation of caspase-3 in apoptosis of human granulosa-luteal cells Endocr J, 52: p. 327-35. [PMID: 16006727]

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